The dose that I will be using is 12.5mg per Kilogram divided into two doses.This comes from previous human use studies. Which for my weight comes out to 1000mg twice a day. I had the Sodium Dichloroacetate powder made into 500mg capsule. I will be taking them on a full stomach and with approximately 16 oz. of water. In order to lower the risk of side effects it has been suggested in some research studies that “ DCA can cause a reversible peripheral neuropathy that may be related to thiamine deficiency and may be ameliorated or prevented with thiamine supplementation. “ (1) The use of thiamine 100mg or more should be used concomittantly with the DCA. I personal am thinking of using Benofotiamine a fat-soluble and more bioavailable and physiologically active form of thiamine. (2)Benofotiamine has been shown to be an effective treatment for patients with diabetic perpherial neuropathy. Though we really don't know what efffect the use of thiamine will have on the Cancer Cell assuming that DCA has any effect on cancer in humans.

After reviewing the research I think that Dr. Michelakis played down adverse effects of DCA. Know doubt DCA has way less adverse effects then conventional cyto-toxic chemotherapy but this drug is not completely benign. Apparently doses greater the 25mg per Kilogram increase the risk of these side effects. One other sugestion would be making sure you have a recent liver function test which you can then follow up after being on the DCA for a week or two. Since DCA can rise liver enzymes.

Remember all this information is just extrapolation of data and no one has the answer till studies are done.

If DCA research translates over to humans this will be a great step forward in cancer treatment.

For those whom can’t wait for human research studies to become available. I wish you the best and never give up hope

And thanks for the kind words.

Blessings,

Omega3

(1) Metabolism. 1989 Nov;38(11):1124-44
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2554095&query_hl=1&itool=pubmed_docsum

(2) Altern Med Rev. 2006 Sept;11(3):238-242
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17217325&query_hl=7&itool=pubmed_docsum

>I have received my order of Sodium DCA from a US medical
>research supply company this week and the order had been
>reduced in size since the demand for DCA exploded after the
>release of the University of Alberta paper. You have both
>cancer researchers and cancer patients seeking DCA. I have
>obtained the DCA for personal use since I have Prostate Ca.
>I can truely understand the frustration of not being able to
>get hold of this possible new cancer treatment.
>
>The dose that I will be using is 12.5mg per Kilogram divided
>into two doses.This comes from previous human use studies.
>Which for my weight comes out to 1000mg twice a day. I had
>the Sodium Dichloroacetate powder made into 500mg capsule. I
>will be taking them on a full stomach and with approximately
>16 oz. of water. In order to lower the risk of side effects
>it has been suggested in some research studies that “ DCA
>can cause a reversible peripheral neuropathy that may be
>related to thiamine deficiency and may be ameliorated or
>prevented with thiamine supplementation. “ (1) The use of
>thiamine 100mg or more should be used concomittantly with
>the DCA. I personal am thinking of using Benofotiamine a
>fat-soluble and more bioavailable and physiologically active
>form of thiamine. (2)Benofotiamine has been shown to be an
>effective treatment for patients with diabetic perpherial
>neuropathy. Though we really don't know what efffect the use
>of thiamine will have on the Cancer Cell assuming that DCA
>has any effect on cancer in humans.

Sounds like you have done a lot of research, as many of us have, on the use of Sodium DCA.

So, here starts "The Open Source DCA Trials"

I wish you success on fighting this cancer. We all are crossing our fingers with hope.

g_generis@hotmail.com

Thanks for posting your wife's experience. This information is so valuable to all of us and much appreciated. Please keep us posted and good luck.

Best to you both.

Heather
TheDCASite Admin & Moderator

Is it in power form? ... as sodium dichloroacetate?

Can you name the health food stores that sell it?

It it sold under some trade name?

In short, where and how can I get my hands on it?

Its worth reading everything on this site Rich, as apparently its illegal to sell DCA to people for cancer treatment - but its not illegal to sell it to people who want to treat animals with the types of cancer that people get.

So in other words, if you wanted to buy DCA to treat a very close or much loved animal, then keep checking this site as there may be a link in the near future which will help people find what they are looking for.

Good Luck (I'm in the same position, I really need to access this drug too).

Thanks for the response.

I apologize for asking about animals. My dog just suddenly got sick with Histiocytic Sarcoma. I came to this site to find DCA for my mother for her Advanced NSC lung cancer. She is anxiously waiting and so am I. I am so grateful to you Heahter for your emails, your forum and support. Its amazing.

So I am asking about DCA for dogs. Can it be prescribed for cancer treatment for dogs? Is it the vet who prescribes it? Or a Vet onocologist? What is the chance of a vet prescribing and giving dca?

After today's meeting with my dog's vet, he isn't recommending anything, preferring comfort. I wasn't ready to give up for my mom's sake, and now I am being asked to do just that with my dog without even a little fight. This world is crazy. Patents, Money, illness - its like one forgets what its like to live a day without thinking and researching cancer.

Diana
g_generis@hotmail.com

1>FAO Rich - health stores don't sell DCA (well, at least they
>don't here in the UK) - I think what was meant was that the
>DCA should be put into the small capsules that other drugs
>and remedies come in, and that these empty capsules can be
>bought in health stores.
>
>Its worth reading everything on this site Rich, as
>apparently its illegal to sell DCA to people for cancer
>treatment - but its not illegal to sell it to people who
>want to treat animals with the types of cancer that people
>get.
>
>So in other words, if you wanted to buy DCA to treat a very
>close or much loved animal, then keep checking this site as
>there may be a link in the near future which will help
>people find what they are looking for.
>
>Good Luck (I'm in the same position, I really need to access
>this drug too).

as you know my wife took DCA for 6 Days and then stopped taking it.
It will be very difficult that she can take it anymore due to less energy, mental and physical. We don't think that here constitution is due to the use of DCA, rather it is the advanced cancer blocking her lymph nodes. At my wifes situation it's very difficult to restart taking DCA.

She is still hoping although the physician are not!
Nevertheless we will post our experience as long we can.

I hope I can help with some details:

The source of sodium DCA:
http://www.sigmaaldrich.com/catalog/search/ProductDetail/ALDRICH/347795

Sigma provides a sodium salt. After disolving in water a lightly acid solution of pH 5 results.

The dose we used (25 mg/kg/day) was described in lactacidose treatment in children up to 19 years. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16651305)

More about clinical toxicology of DCA you will find here:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9703483

That being said I can truly empathize with you since I am in the same position of many of you reading this message for yourself or your loved ones whom you might be looking for hope. I have been recently diagnosis with metastatic prostate cancer at only 46 years of age. And have been looking for alternative treatments for the last 4 months.

I have been able to obtain DCA since I am a physician and have worked with off label medication for many years in my medical practice. I have made a personal decision that once I have had some experience using DCA on myself and find there to be no major issues .I will be glad to help other individuals whom are stage 4 cancer patients only whom visit with more for a initial consultation. I will give more details as I see how this progresses

Blessings,

Omega3

Diana

I wish you the best. Thank you for your posts.

Good luck to you!

"Z"

Look forward to reading your posts, "Z".

Sandra

Another avenue I've been looking at is telomerase inhibitors http://www.geocities.com/prime3end/
http://www4.utsouthwestern.edu/cellbio/shay-wright/

And this looked interesting
http://www.stemtechhealth.com/FAQ.asp

I have been reading about bioidentical hormones, and how they help the immune system. Do you think DHEA and HGH are some hormones that can boost the immune system. Is there a difference in the homeopathic vs prescription type DHEA or HGH?

Thank you
Diana

>I am very saddened by the difficulty that everyone is having
>in obtaining DCA. But the use should really be restricted to
>individuals, which have no other alternatives cancer
>treatments left. Remember that there is still no confirmed
>evidence that the results from mice will translate over to
>humans. Also we don't really know how long treatment should
>be continued 1 month, 4 months, 6 month or forever. We don't
>even know what the ideal dose Dr. Michelakis in his filed
>use patent give a dosage range between 10-100 mg per
>kilogram of bodyweight. What will be the ideal dose?? How
>severe will the side effects manifest i.e. peripheral
>neuropathy, disturbed gait, and elevated liver functions and
>possible carcinogenicity. What reaction will this drug have
>on any other medication you are currently on? Many, many
>questions with no clear answer but a definite reason for
>hope. This new treatment may prove to be an effective way
>of treating various cancers and may become part of a new
>class of anticancer drugs based on the inhibition of tumor
>metabolism.
>
>That being said I can truly empathize with you since I am in
>the same position of many of you reading this message for
>yourself or your loved ones whom you might be looking for
>hope. I have been recently diagnosis with metastatic
>prostate cancer at only 46 years of age. And have been
>looking for alternative treatments for the last 4 months.
>
>I have been able to obtain DCA since I am a physician and
>have worked with off label medication for many years in my
>medical practice. I have made a personal decision that once
>I have had some experience using DCA on myself and find
>there to be no major issues .I will be glad to help other
>individuals whom are stage 4 cancer patients only whom visit
>with more for a initial consultation. I will give more
>details as I see how this progresses
>
>Blessings,
>
>Omega3

Medication:
Lupron injections every three months
Sodium DCA 98% powder Ph 5.0 Dosage 25mg per kilogram bodyweight daily
powder placed into size "0" capsule at 500mg each=2 capsules twice a day

Supplementation:
Benfothiamine (lipid soluble thiamine) 150mg twice a day

Week 1
Have been using for one week NaDCA have noticed no side effects will get routine blood work done this week to check liver and kidney function, Will further check my PSA after being on NaDCA for two months since the lupron therapy has hit a plateau and current PSA is still very elevated if PSA comes down significantly effect would be atributed to DCA

Medical Disclaimer:
This information is for educational purposes only. It should not be used in place of a visit, call, consultation or the advice of your physician or other qualified health care provider. Always consult with your physician or other qualified health care provider before embarking on a new medical treatment, diet or fitness program.

my brother Vincent (46 years old) has been diagnosed on the 14th of december 2006 with pancreatic cancer.

It was deemed inoperable and already at stage 4.

The initial scan showed that the cancer had spread to his liver,
and that most of his liver is covered with tumours. His chemotherapy
treatment started on the 17 of december and ended on February 7th after 6 treatments of gemcitabine (gemzar) - that he received every week for 30 minutes. After the initial chemotherapy treatment, Vincent had another scan that revealed that his tumours had somewhat progressed. The oncologists did not specify the extent of this progression, but stated that in their opinion, chemotherapy
treatments would not be useful and should be stopped!!! Oncologists in his province (Quιbec, Canada) are no longer in a position to help us since they have no additional treatments to offer.

This forum has provided some hope and some answers. Please keep up the good work.

Vincent wants to try DCA so we are in the process of trying to get some product and a physician to help monitor the treatment. Info on different current available sources would be very useful.

Any undated information as of the progress of your treatment and or suggestions if your initial dosage and vitamin suplement has not been successful.

Same thing about any clinical trials and or protocol (Indiana?) would also be very helpful.

Once Vincent will have started to use DCA we will report the process in this forum.

Thank you in advance for your much anticipated response.

God bless all.

anechoic2001@yahoo.ca

"RE: Dr. Tim's reaction to DCA at ABC news website"
In response to message #22

Hi Loni: If you are still looking, I had two B.C. pharmacies say they could supply. waltgooder@nucleus.com

I cannot verify the availability. Wishing you all the best in our difficult situations.

See my post about Clinical Trials and keep up your concern, care and love for OUR #1 Paisan.

Molto molto piacere...

Ciao,
"Z"

PS sorry to everyone else about the personal post...

thank you for responding.

Vincent is seeing his familly doctor today (tuesday) and will try to secure a prescription. I will be in Montreal tomorow to assist him in a meeting with a second opinion oncologist.

Vincent was not given Terceva with his 6 Genzar treatments, and the subsequent scan (after the treatment) showed that the tumors had not stabilized or shrunk.

No clear information was given though by his oncologist on the scope of the changes. I know he was in shock about the results and the fact that his doctors seemed to have given up.

He is now on another treatment of chemo which has a regimen of 5 Fluoro-uracile and folic acid. This since the 21rst of february every week for a duration of 30 minutes. Another scan might be done today.

He also has been fitted with a drain to get the fluids out of the abominal cavity.

We have his file with the results of the last two scans (the initial one and the one after the first chemo) but I have not seen the last one yet.

As you can imagine his spririt is beeing tested and my hope is that DCA will have a positive impact on his illness when we get it. Time however is not on his side.

Bless all who responded and are helping.

Anechoic

All the best,
Loni

I have posted the name and phone number of this pharmacy before to others and the pharmacists are saying they just need a 2 or 3 day turnaround (their supplier is in Texas). Then, if you prepay, they could airmail it to you in capsule form.
Here it is again:
J.E. Pierce Apothecary
Brookline, MA

Phone Number:
1-617-566-4080 (ask for Steve, the pharmacist).

You need to make payment arrangements and probably can fax your prescription to them.
Good luck. This might also be a good place to get your Thiamine supplement.

I will go back on my budwig diet again starting today until something better comes along that I can get my hands on. Please do not be to dismayed and please know we are all with you and your Mother. God Bless D C A research and Gods Speed to those brave souls here helping us all.

L

http://www.burzynskiclinic.com/

I wish you and your wife the best,
Sandra

rzrobecki@gmail.com

You can get it from Pet DCA in the US. I paid £8.01 in customs
charges on 50 grams when it arrived. Takes about 2 weeks.

Good luck.

Michael

Thanks.

Hope this brings support for people based over here. Seems harder to get information about the drug in UK than america and canada where it has been widely reported on.

Many Thanks

Elliott