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Blocking Metastasis by controlling acidity


Most cancer patients die from metastatic tumors, not the original tumor. It is critical to take efforts to slow or stop metastasis. Altering your pH might be an effective and safe action you can do yourself.

Here are some articles showing that low pH (acidic) is indeed important in encouraging metastasis.

Acidic Extracellular pH Promotes Experimental Metastasis of Human Melanoma Cells in Athymic Nude Mice (2006)
"In summary, the present study shows that acidic pH promotes experimental pulmonary metastasis of A-07, D-12, and T-22 human melanoma cells in athymic nude mice by up-regulating the expression of the proteolytic enzymes MMP-2, MMP-9, cathepsin B, and cathepsin L and the proangiogenic factors VEGF-A and IL-8. One significant implication of this observation is that treatment strategies involving deliberate tumor acidification may have undesirable metastasis-promoting side effects and thus should be avoided. Furthermore, clinical studies investigating the possibility that the pH of the primary tumor may be an important prognostic parameter for melanoma patients are highly warranted."

Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines (1992)
"These results suggest that the acidic environment formed around tumor tissues may be an important factor in invasion and metastasis of some types of tumors."

pH Nanoenvironment at the Surface of Single Melanoma Cells (2007)
" Thus, cells create a pH nano-environment that promotes cell migration by facilitating cell adhesion at their front and the release of cell/matrix contacts at their rear part."

Acidic pH enhances the invasive behavior of human melanoma cells (1996)
"Similarly, cells cultured at acidic pH were more aggressive than control cells when tested at the same medium pH. These data indicate that culturing of cells at mildly acidic pH induces them to become more invasive."

Effects of the coral calcium as an inhibitory substance against colon cancer and its metastasis in the lungs .(2000)
"The metastasis of the cancer cells in the lungs was significantly inhibited at a higher dose of Coral Calcium."

Does the tumor microenvironment influence radiation-induced apoptosis? (2006)
"Conclusions: Hypoxia, low glucose and acidosis influence radiation-induced apoptosis and thus may be detrimental to radiotherapy. "

Causes and Consequences of Increased Glucose Metabolism of Cancers (2008)
"we propose that glycolysis is elevated because it produces acid, which provides an evolutionary advantage to cancer cells vis-à-vis normal parenchyma into which they invade."

Acid pH in Tumors and Its Potential for Therapeutic Exploitation (1989)
"Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues."

This 1948 article, http://www.jbc.org/cgi/reprint/173/1/25.pdf shows that human plasma pH is around 7.3 to 7.4.

Citric acid is commonly used to reduce acidity.

List of alkaline and acidic foods:


The.alkalizeforhealth.net site has a nice summary of ways to alkalize yourself. http://www.alkalizeforhealth.net/salivaphtest.htm

Contents of lemon juice