lactic acidosis Symptoms nonspecific: anorexia, hyperpnoea, altered consciousness
Signs and symptoms of lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain and thirst. Doctors should suspect lactic acidosis in patients presenting with acidosis, but without evidence of hypoperfusion or hypoxia.

The list of signs and symptoms mentioned in various sources for Lactic Acidosis includes the symptoms listed below:
Nausea
Vomiting
Hyperventilation - to remove CO2
Abdominal pain
Lethargy
Shock
Severe anemia
Low blood pressure
Heart rhythm irregular
High heart rate
Rapid pulse
Acidosis
Acetone smelling breath

Lactic acidosis is a condition caused by the buildup of lactic acid in the body. It leads to acidification of the blood (acidosis), and is considered a distinct form of metabolic acidosis.

The cells produce lactic acid when they use glucose for energy in the absence of adequate oxygen. If too much lactic acid stays in the body, the balance tips and the person begins to feel ill.

Note that Lactic Acidosis symptoms usually refers to various symptoms known to a patient, but the phrase Lactic Acidosis signs may refer to those signs only noticable by a doctor.

Lactic acidosis occurring from associated underlying diseases, known as type B1, has been identified with diabetes mellitus, bowel ischemia, severe iron-deficiency anemia, liver disease, alcoholic ketoacidosis, pancreatitis, malignancy (leukemia, lymphoma, lung cancer), infection, renal failure, seizures, heat stroke, pheochromocytoma, thiamine deficiency, short gut syndrome, and other carbohydrate malabsorption syndromes.

Portions of this post can be found here at this emedicine website.

http://www.emedicine.com/emerg/topic291.htm

Hope this info is useful,

RJ

Now that people are aware that low blood sugar can be a side effect, they should just take care to eat more often, and make sure to have a snack with them at all times. My mother-in-law was a diabetic. People learn to live their whole lives having to watch their blood sugars. It can be done in a healthy way, without having to 'feed' the cancer with sugar.

I try to eat regularly. I lapsed on that day with not eating for four hours. I did not really expect the DCA to have an effect on my metabolism a few days after discontinuing it, but obviously it did.

You are right diabetics should eat on a regular basis. Plus they should take their medicines on a regular basis.

Simple sugars are the best way to treat hypoglycemic episodes as they get into your system the fastest orally.

You have been very careful with your words, so as not to discourage others, while still making them aware of your results.

I'm sure you are dissapointed to an extent that few, including myself, could fully understand.

I hope people pay attention to what you have said, and not turn a blind eye to it or dismiss it as an anomaly. The truth is, there are hundreds of potential chemotherapies that cured lots of rats but never helped a human being.

The fact that you're experiencing the side effects has me concerned for many of the people here taking DCA. I wish them the best, but felt it important to express that.

A healthy human sized rat would be making for itself around 10g of ascorbate every day. The same rat under sickness or stress would be making ten to twenty times as much ascorbate.

It is quite possible that what was observed in the rat model will only translate into the human if the ascorbate discrepancy is compensated by dietary supplementation in humans to bring these two systems into closer alignment.

http://www.thedcasite.com/dcaforum/DCForumID1/58.html

Not saying you're wrong but what specifically makes you think that ascorbate has anything to do with this particular metabolic function -the shifting from glycolysis to glucose oxidation.

What implying is that the 10s of thousands of studies performed with rats and mice (presumably) may be invalid - and that the
researchers never considered and discounted this difference.

Can you refer me to any sites/articles which documents this
difference and possible significance - I haven't been able to find any.

Thanks,

Larry

What Derek and others are saying is that we believe that the high rat ascorbate levels in conjunction with DCA are a critical part of the tumour shrinkage success in the rat experiment and human supplementation with additional antioxidants will go some way towards duplicating the rat success in humans.

If you do your literature search covering" Dichloroacetic acid " Cancer ", "Ascorbic Acid", "R-Lipoic Acid" etc you will come across some interesting references. Cover both the standard scientific Literature and Patents.
I do not believe in giving students all the answers simply because none of us have all the answers. The real quest is learning to question, ask the right questions then research the answers for yourself .

We look foreward to your continued participation in this forum and would encourage you to specialise in this area of Research.

John A
Research Chemist

The last week of DCA was the worst week, symptom-wise, for me. It lasted about a week after I discontinued it. I had numbness in my feet and hands, tremors, weakness, severe malaise, and just a feeling that I was going to die. The episode of hypoglycemia because of the DCA was the worst feeling I have ever experienced, and I may have died if I did not get some sugar into my system at that time. Gratefully, all those symptoms resolved by the time I had surgery.

I am starting next week on a Phase II trial of a new angiogenesis blocker. These angiogenesis blockers were cover stories in the nineties as the cure-all for cancer. They did not live up to their expectations. My oncologist is positive that this new generation angiogenesis inhibitor may actually work as theorized.

Thanks for your well wishes.

I wish all cancer patients on this site a remission of their disease. Communicate and work with your doctor to help you.

Thanx,
John C.

Glad you are up and around. Can I ask two more questions? The amount you were taking: 2 x25mg/kg daily-can you tell me what that equals in grams?? Thanks -also

Can you tell me where I might find info on the Ph 2 you are taking. I am looking into trials for my Dad. Thanks very much and I'll pray that it works for you. Sounds like your doctor is feeling positive which is great!

Sunitinib is approved for renal cell carcinoma and gastrointestinal stromal tumor. There are phase II trials for other cancers going on.

I weigh about 100kg, so I was taking 2.5 grams twice daily. The dosage of DCA is according to the weight of the patient. A patient weighing more would take proportionally more, and a patient weighing less would take proportionally less.

Best of luck with the sunitinib (Sutent). My dad was on it for 3 months for advanced renal cell carcinoma. He had a mixed result-the peritoneal lymph nodes completely disappeared, but new tumours appeared in his chest. Side effects were not great but tolerable. In rcc, sunitinib stabilises disease for about 8 months in around 60% of people. He is now on sorafenib (nexavar), which is also an VEGF inhibitor, but works in a slightly different way. We shall wait and see.

God bless

So glad you are doing better. Thank you for sharing your experience with us all. After reading your past posts, I decided not to increase my dosage, and have been able to comfortably maintain a dose of about 15-20mg/kg/day for 2 months. I think it's safe to say that a dose of 50mg/kg/day is not advised, after what you experienced.

I wondered if you have read the posts on this thread http://www.thedcasite.com/dcaforum/DCForumID1/79.html (about polarized mitochondrial) as they may possibly explain why it seems DCA did not work for your specific type of cancer - sarcoma.

Best wishes,
Sandra

There is no significant difference between the two readings - If it was 15, yes, but 13.11 to 13.33 ? over a 6 month period is not significant. PSA doubling rate is one indicator, look at how many years it is going to take you to reach a PSA of 26, if things continue at the present rate.
That is from the optimist
The pessimist wonders why it has not moved.
The neutralist says it is hard to understand what is happening, but it is not getting worse.
Gleason of (3+4) should behave more like a 6 than 8 and it looks like it does.
You feel OK? keep going. You cant imagine how I felt going from 0.1 to 0.2 to 1.2.... miffed, real real miffed..