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dimitriskadmin
Member since Mar-19-08
238 posts
Dec-25-09, 02:31 PM (PST)
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"DCA causes depression at high dose"
 
   My sister takes DCA for the last two years without any side effects. It looks like it works for her case but at doses higher than 25 mg/Kg.

Now she takes DCA 7 days on 3 days off, at 40 mg/Kg. She tolerates it very well, but at 6th or 7th day she gets very depressed. This lasts only for the two last days of treatment, when DCA concentration in her blood is at the highest level (close to 80mg/Kg).

Is this side effect known?
Do you have any idea what might be causing this depression?


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DCA causes depression at high dose [View All], dimitriskadmin, 02:31 PM, Dec-25-09, (0)  
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robmx
Member since May-25-09
59 posts
Dec-25-09, 11:12 PM (PST)
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1. "RE: DCA causes depression at high dose"
In response to message #0
 
   >My sister takes DCA for the last two years without any side
>effects. It looks like it works for her case but at doses
>higher than 25 mg/Kg.
>
>Now she takes DCA 7 days on 3 days off, at 40 mg/Kg. She
>tolerates it very well, but at 6th or 7th day she gets very
>depressed. This lasts only for the two last days of
>treatment, when DCA concentration in her blood is at the
>highest level (close to 80mg/Kg).
>
>Is this side effect known?
>Do you have any idea what might be causing this depression?

How old is your sister, does she take B-1?


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dimitriskadmin
Member since Mar-19-08
238 posts
Dec-25-09, 11:33 PM (PST)
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2. "RE: DCA causes depression at high dose"
In response to message #1
 
   My sister is 52 and for the last two years she's been fighting a ER- PR- breast cancer with lung metastases. She had no rad or chemo so far, but last October she had to take one round of regional chemotherapy stop-flow with very good response. So, she did a second round of the same treatment 10 days ago. DCA works for her case, since she has experienced very rapid drop of tumor markers while taking doses higher than 25mg/Kg. She also takes 500mg benfotiamine and some B2,B6,B12, folic acid, D3, lipoic acid and coQ10. All these are for supporting DCA treatment.
There are many more supplements she takes than I have descriped here:
http://www.thedcasite.com/dcaforum/DCForumID2/266.html

The interesting thing about her depression is that it happens only for the last two days of her treatment (when drug concentration is very high) and moves away after taking DCA break. I wonder if anyone else has experienced similar problem, and if you know a reasonable explanation for this.

Most people in this forum take DCA at a "5 days on 2 days off" schedule. However, Medicor clinic uses a longer schedule, 14 days on 7 days off, and at higher doses. I wonder if they have experienced similar side effects.


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satx
Member since May-9-07
106 posts
Oct-24-10, 12:34 PM (PST)
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5. "RE: DCA causes depression at high dose"
In response to message #2
 
   My experience is that DCA causes a "chemo fog" where I just don't have mental energy or clarity. This is not noticeable since it's very slight and I can still function. But 2 days after I stop DCA, and this has happened at least 3 times, I wake and feel so much better, mentally more clear, mentally energetic (creative, positive thoughts).

I could imagine that this mental fog could also be seen as a kind of depression.

Even with benfotiamine, DCA caused a tingling and numbness in my toes that last from stopping DCA in Nov 07 until at least a year or two later. I can't tell how long because I just figured, after many money, that it was permanent, but it's definitely gone now.


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vikas
Member since May-5-09
8 posts
Jan-05-10, 01:00 PM (PST)
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3. "RE: DCA causes depression at high dose"
In response to message #0
 
   >My sister takes DCA for the last two years without any side
>effects. It looks like it works for her case but at doses
>higher than 25 mg/Kg.
>

I am really glad that DCA is working for your sister. May I ask you where you are getting your DCA?


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dimitriskadmin
Member since Mar-19-08
238 posts
Jan-10-10, 02:10 AM (PST)
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4. "RE: DCA causes depression at high dose"
In response to message #3
 
   www.buyDCA.com

I live in Greece and I've never had problem ordering.


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parachuteadmin
Member since Mar-20-07
69 posts
Oct-25-10, 04:33 AM (PST)
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6. "RE: DCA causes depression at high dose"
In response to message #0
 
   For my depression during radiation and androgen blockade, Sandra recommended S-adenosylmethionine also known as SAMe <http://en.wikipedia.org/wiki/S-adenosylmethionine> and Theanine. I found them very helpful and still take 200mg SAMe morning and evening.

Note, SAMe is not recommended for individuals with bipolar disorder.



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Vitaminboss
Member since Mar-3-07
101 posts
Nov-25-10, 12:14 PM (PST)
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7. "RE: DCA causes depression at high dose"
In response to message #6
 
   >For my depression during radiation and androgen blockade,
>Sandra recommended S-adenosylmethionine also known as SAMe
><http://en.wikipedia.org/wiki/S-adenosylmethionine> and
>Theanine. I found them very helpful and still take 200mg
>SAMe morning and evening.
>
>Note, SAMe is not recommended for individuals with bipolar
>disorder.


SAME is tumor rocket fuel in more than one biochemical pathway. Via increased poly-amine synthesis and methylation. Almost all cancers are already hypermethylated.


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