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DCA News
unregistered user
Mar-24-07, 01:25 AM (PST)
 
"This study is currently recruiting patients."
 
   Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia

This study is currently recruiting patients.
Verified by FDA Office of Orphan Products Development May 2000

Find it here;

http://clinicaltrials.gov/ct/show/NCT00004493?order=2


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This study is currently recruiting patients. [View All], DCA News , 01:25 AM, Mar-24-07, (0)  
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DCA News
unregistered user
Mar-24-07, 01:33 AM (PST)
 
1. "RE: This study is currently recruiting patients."
In response to message #0
 
   Prevention of Dichloroacetate Toxicity

This study is currently recruiting patients.

Verified by FDA Office of Orphan Products Development January 2002

This is a study to determine the safety of dichloroacetate (DCA) with a low-tyrosine diet given with or without nitisinone (NTBC) in children with chronic lactic acidosis (CLA).

Find it here;

http://clinicaltrials.gov/ct/show/NCT00031161?order=45


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DCA News
unregistered user
Mar-24-07, 01:43 AM (PST)
 
2. "ABSTRACT"
In response to message #1
 
  
http://jcp.sagepub.com/cgi/content/full/46/12/1449

Human Kinetics of Orally and Intravenously Administered Low-Dose 1,2-13C-Dichloroacetate


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DCA News
unregistered user
Mar-25-07, 08:14 PM (PST)
 
6. "RE: This study is currently recruiting patients."
In response to message #1
 
   Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia.

ClinicalTrials.gov Identifier: NCT00004353

Found Here:

http://clinicaltrials.gov/ct/show/NCT00004353


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DCA News
unregistered user
Mar-25-07, 07:44 PM (PST)
 
3. "Chronic lactic acidosis and cancer"
In response to message #0
 
  
Chronic lactic acidosis in a patient with cancer: Therapy and metabolic consequences

http://www3.interscience.wiley.com/cgi-bin/abstract/112673404/ABSTRACT?CRETRY=1&SRETRY=0

Worth a look!


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DCA News
unregistered user
Mar-25-07, 07:54 PM (PST)
 
4. "More on Chronic lactic acidosis and cancer"
In response to message #3
 
   From the Mayo Clinic - Letter to the editor. This goes over the emergency aspect of lactic acidosis with regards to cancer.


http://www.mayoclinicproceedings.com/pdf%2F8111%2F8111le4.pdf


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DCA News
unregistered user
Mar-25-07, 08:04 PM (PST)
 
5. "Symptoms lactic acidosis and cancer"
In response to message #4
 
   Lactic Acidosis Symptoms:
Initial symptoms of high lactate levels include nausea, lack of appetite and malaise, as well as fatigue and difficulty in breathing. Muscle pain and numbness or tingling sensations have also been reported. In lactic acidosis, the liver may become swollen and tender, and liver enzymes may be elevated. Symptoms of acute lactic acidosis include difficulty in breathing and hyperventilation. Diagnosis is usually confirmed with a liver ultrasound.

Fourteen cases of rapidly ascending neuromuscular weakness mimicking Guillain-Barré ³yndrome have been associated with the use of NRTIs. Five of these cases were fatal. In most of these cases, non-specific symptoms and signs associated with lactic acidosis preceded the development of neuromuscular problems.

The long-term consequences of large elevations in lactate levels for those with pre-existing liver damage is unknown.


Find it Here:

http://www.aidsmap.com/cms1032603.asp


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