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Conferences General DCA Discussion Topic #90
Reading Topic #90
Gordon
unregistered user
Apr-29-07, 01:49 AM (PST)
 
"how to make DCA (for chemists only)"
 
   here is an old reference to one way to make DCA. Of course the DCA made should be converted to the sodium or potassium salt before use in a biological subject. The reference also gives references to other methods of preparation.

This preparation method uses ether and anyone not familiar with ether's tendencies to sometimes form ether-peroxide (a violent explosive) should consult a chemist familiar with its safe and proper use.


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gordon
Member since Apr-27-07
3 posts
Apr-29-07, 01:52 AM (PST)
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1. "RE: how to make DCA (for chemists only)"
In response to message #0
 
   When I used HTML for the link, the link disappeared in the posted version, here is the link without html:

http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv2p0181

Gordon


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gordon
Member since Apr-27-07
3 posts
Apr-29-07, 02:14 AM (PST)
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2. "RE: how to make DCA (for chemists only)"
In response to message #0
 
   After reading the reference carefully I realized that calcium DCA is made as an intermediate step. That should be just fine for pharmaceutical use. So, omit the HCl acidification step and the ether extraction. Someone should check this. It should probably be also possible to use potassium (or sodium) carbonate instead of calcium carbonate and just to directly to K or Na DCA. Simple and it should work.

Gordon


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gordon
Member since Apr-27-07
3 posts
Apr-29-07, 02:37 AM (PST)
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3. "RE: how to make DCA (for chemists only)"
In response to message #2
 
   Of course if you shorted the synthesis as above, it would be necessary to find a way to get rid of the highly poisonous sodium cyanide.

Gordon


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