the DCA site - Updating you on DCA and Cancer

DCA Discussion Forum

Subject: "DCA and the MAAI pathway"     Previous Topic | Next Topic
Printer-friendly copy     Email this topic to a friend    
Conferences DCA Research Topic #83
Reading Topic #83, reply 14
davidportia
Member since Jul-23-08
61 posts		 Feb-09-09, 06:01 AM (PST)
Click to EMail davidportia Click to send private message to davidportia Click to view user profileClick to add this user to your buddy list  
14. "RE: DCA and the MAAI pathway"
In response to message #11
 
   >Hmmm.... I've been trying to understand the catabolism of
>tyrosine to thyroxine (a thyroid hormone) to see whether or
>not DCA would cause hypothyroidism. I now think that this
>is a separate pathway, and doesn't involve the MAAI one
>(which DCA inhibits). So, I don't believe DCA use would
>lead to hypothyroidism.
>
>Here is the metabolic pathway for tyrosine:
>http://www.genome.jp/kegg/pathway/map/map00350.html
>
>You can see the path that leads from tyrosine to L-thyroxine
>is vertical. The one from tyrosine to Maleylacetoacetate is
>horizontal (to the left).
>
>So, at this point probably the best thing to do is try to
>eat more foods lower in tyrosine when taking DCA (fruits and
>vegetables), and take time off DCA.

Hi, Sandra,
Yes, I am thinking of time-off on DCA, but not sure how long on the time-off. As per Mack, it took 8 weeks for animal model. I think it maybe too long for my dad if LDN does not work to curb the tumor growth. Right now, I think I should give LDN at least 20 days before cutting off DCA. What dosage would be the best if I pursue 8-weeks on and 8-weeks off on DCA?
I hope we can come up with a dosing and time regimen for DCA that ensures MAAI does not get depleted at least for now, if we do not have access to other proven alternative meds. Any suggestions?
Best regards,
David


  Alert | IP Printer-friendly page | Edit | Reply | Reply With Quote | Top

 DCA and the MAAI pathway [View All], Mack, 06:01 AM, Feb-05-09, (0)  

Conferences | Topics | Previous Topic | Next Topic