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Joy
unregistered user
Apr-08-07, 02:27 AM (PST)
 
"Successful Results"
 
   My father Terry who is 62, was diagnosed in September of 2006 with a very rare form of bladder cancer called adenocarcinoma which is only found in 1 to 2 percent of bladder cancer patients. This form of cancer is highly aggressive and as a result was given approximately 6 months to 1 year to live. After the initial diagnosis, he underwent 2 surgeries. The first to remove the tumor from inside the bladder and second to remove the bladder entirely. The doctors were unsuccessful with removing the bladder due to the extent of the cancer growth. The tumor was actually on top of the bladder as well as attached to the peritoneum making it impossible to remove. The doctors also stated that pathology results had confirmed that the cancer was microscopically everywhere. To make matters worse, my father had received a heart transplant in July of 2002 due to heart disease. Because of his heart transplant he must take anti-rejection medications to keep his immune system suppressed. The immune system must be close to nonexistent to prevent his heart from rejecting. This has prevented him from having any form of cancer treatment. The doctors explained how there was nothing that could be done and basically sent him home to die. Since his diagnosis I have been researching for a cure with minimal side effects because of the extensive list of medications that my father is currently taking, which is about 25 pills a day. I had been emailing a doctor on-line with concerns of my fathers eating habits, he had dropped weight from 158lbs. to 133lbs. and was experiencing nausea, vomiting, dizziness. The doctor stated that my father was suffering from cachexia, which is common in final stages of cancer. It where the body actually eats itself and that I should purchase a product called Haelan 951. I later found that Haelan products were more than I could afford so I looked at the contents and purchased them individually from a vitamin supplier. At that same time I found and purchased DCA and began treatment for my father. Today has been four weeks of treatment, my father uses 1/4 teaspoon of DCA mixed with 8 ounces of water once a day in the morning along with vitamins Co Q-10, Soybean, L-glutamine, Omega 369, Pro-biotic Acidophilus, Noni, B1, and Zinc. Within 2 weeks of treatment he had noticeable improvements in appetite and was experiencing less nausea. Currently, he has not experienced any vomiting, nausea, or dizziness. He now weighs 144lbs. which is an 11 lbs weight gain in about 2 weeks, his appetite has greatly improved, he is now walking on his own which he was unable to do prior to treatment and amazingly is exercising. He has also regained muscles in his arms along with the color to his skin. He experiences bladder spasms thats directly related to the tumor on the bladder that has also subsided. There is no doubt in my mind or my families that DCA is the direct result of his improvements, simply because my father has not received any other form of treatment. I would also like to add that he has not experienced any side effects. My mother also informed me that my father went 3 and 1/2 hours without his pain medication yesterday and did not complain. Unfortunately we have not had any CT scans or monitoring from his doctors due to their lack of support but we can clearly see that something positive is happening. If anyone has any questions please feel free to ask, I will do anything I can to help.

God Bless
Joy


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Successful Results [View All], Joy , 02:27 AM, Apr-08-07, (0)  
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Sandramoderator
Member since Feb-27-07
1178 posts
Apr-08-07, 03:00 AM (PST)
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1. "RE: Successful Results"
In response to message #0
 
Joy,

That's AMAZING!! I think we are all about to see more results like this! I'm so happy your father is getting such remarkable improvement with DCA!

Thanks for your post! God Bless!

Sandra


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scott
unregistered user
Apr-08-07, 04:13 AM (PST)
 
2. "RE: Successful Results"
In response to message #0
 
   Hi Joan-

I'm very happy to hear such good news. I was wondering: is it possible it is the nutrients that are restoring your father's strength/muscle? Also-do you get these nutrients in a powdered form or do you order them in a pill? I am trying to put together a weight gain shake for my Dad and if his current treatment fails, I am going to suggest DCA for him also..put I want to include what is working for others. Thanks and congratulations...


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scott
unregistered user
Apr-08-07, 04:17 AM (PST)
 
3. "RE: Successful Results"
In response to message #2
 
   Sorry-I meant Joy


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Joy
unregistered user
Apr-08-07, 04:31 AM (PST)
 
5. "RE: Successful Results"
In response to message #2
 
   >Hi Joan-
>
>I'm very happy to hear such good news. I was wondering: is
>it possible it is the nutrients that are restoring your
>father's strength/muscle? Also-do you get these nutrients in
>a powdered form or do you order them in a pill? I am trying
>to put together a weight gain shake for my Dad and if his
>current treatment fails, I am going to suggest DCA for him
>also..put I want to include what is working for others.
>Thanks and congratulations...

Hi,

The vitamins are in pill form. It maybe possible that the nutrients are helping however, my father was taking the noni and a multi-vitamin before the DCA and was not showing any improvement like we have seen since using DCA. Also, I am sure that the nutrients are not stopping the spasms from the tumor. So, like I previously stated I believe that my father's improvements are from the DCA. I wish you the best for your father.


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rtshinn
Member since Mar-7-07
194 posts
Apr-08-07, 02:55 PM (PST)
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9. "RE: Successful Results"
In response to message #5
 
   Very interesting news indeed!
A CT scan would be great, if the insurance would pay for it!
A lot of us are waiting for objective measurements.


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Willis
Member since Feb-16-07
18 posts
Apr-08-07, 04:17 AM (PST)
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4. "RE: Successful Results"
In response to message #0
 
   Please have a scan done.


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ConnieinReno
unregistered user
Apr-08-07, 06:21 AM (PST)
 
6. "RE: Successful Results"
In response to message #4
 
   Joy,

I am so happy for you, your Dad, and your family - that's quite a story of his return from near death to where he is today, and after only a month of DCA treatment. You must be elated to see these kind of results. His success will mean a great deal to those individuals who have been waiting patiently for some favorable news on DCA use.

Did I read correctly that he took 1/4 teaspoon just once a day in the morning?

Thank you for letting us all know about this on the DCA site.

Connie


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Joy
unregistered user
Apr-08-07, 04:55 PM (PST)
 
10. "RE: Successful Results"
In response to message #6
 
   >Joy,
>
>I am so happy for you, your Dad, and your family - that's
>quite a story of his return from near death to where he is
>today, and after only a month of DCA treatment. You must be
>elated to see these kind of results. His success will mean
>a great deal to those individuals who have been waiting
>patiently for some favorable news on DCA use.
>
>Did I read correctly that he took 1/4 teaspoon just once a
>day in the morning?
>
>Thank you for letting us all know about this on the DCA
>site.
>
>Connie

Hi,
Yes he only takes 1/4 teaspoon a day mixed with 8 ounces of water.
We started him on a low dose because we were afraid of possible side effects.


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jackf
unregistered user
Apr-12-07, 03:36 PM (PST)
 
38. "RE: Successful Results"
In response to message #10
 
   Joy, does your father drink the whole 8 oz at once or sip it all day?
That could make a difference, couldn't it?
My wife's sister is trying DCA now and she is sipping a 10/mg/kg
daily dose all day in drinking water.

thanks, Jack F


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Joy
unregistered user
Apr-28-07, 11:48 PM (PST)
 
53. "RE: Successful Results"
In response to message #38
 
   >Joy, does your father drink the whole 8 oz at once or sip
>it all day?
>That could make a difference, couldn't it?
>My wife's sister is trying DCA now and she is sipping a
>10/mg/kg
>daily dose all day in drinking water.
>
>thanks, Jack F


Hi,

He drinks it all at once

Joy


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sade00
unregistered user
Apr-08-07, 10:13 AM (PST)
 
7. "RE: Successful Results"
In response to message #0
 
   Hi joy

Thank you so much for you sharing this precious experience to us. That is so amazing result. God bless your father. I pray for him.

Please give me some information about DCA. Where are you bought DCA? From buy DCA site?
Which is DCA product your father taking? Is it sodium DCA or Pet DCA? alternatively , you can email me, zzu82@hotmail.com. Thank you very much.

My old brother who is 31 has a same situation with your father. He had a liver transplant surgery in July 2006. Unfortunately, just two month after his surgery, a cancer tumour was found in his adrenal gland. The tumour size is 43mm+37mm+45mm, CT result is65HU, and also there is some nodus in his lung. Recently, Because of this liver tumour he received a period chemistry radiation treatment. This chemistry radiation not only has a strong side effect, also totally disorder his digestive system. But Your father's experience must cheer him up!!

Please keep post , i will check back everyday.



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Joy
unregistered user
Apr-08-07, 05:12 PM (PST)
 
11. "RE: Successful Results"
In response to message #7
 
   >Hi joy
>
>Thank you so much for you sharing this precious experience
>to us. That is so amazing result. God bless your father. I
>pray for him.
>
>Please give me some information about DCA. Where are you
>bought DCA? From buy DCA site?
>Which is DCA product your father taking? Is it sodium DCA or
>Pet DCA? alternatively , you can email me,
>zzu82@hotmail.com. Thank you very much.
>
>My old brother who is 31 has a same situation with your
>father. He had a liver transplant surgery in July 2006.
>Unfortunately, just two month after his surgery, a cancer
>tumour was found in his adrenal gland. The tumour size is
>43mm+37mm+45mm, CT result is65HU, and also there is some
>nodus in his lung. Recently, Because of this liver tumour he
>received a period chemistry radiation treatment. This
>chemistry radiation not only has a strong side effect, also
>totally disorder his digestive system. But Your father's
>experience must cheer him up!!
>
>Please keep post , i will check back everyday.

Hi,
I ordered the DCA from buydca.com. I am sorry to hear about your brother, I will pray for him. Once my father was diagnosed with cancer they cancelled one of his anti-rejection medications because one of the side effects was cancer. You should ask your doctor if your brother is taking any medications that may have caused the cancer and if so, he should not be taking them. According to my fathers coordinator at the hospital, he should have been taken off that particular medication 2 years ago. The doctors advised my dad not to do radiation because it most likely would not help his type of cancer and could lead to more problems such as bleeding. However, they did advise that it would probably help with his pain. My father is very exicted. He asked his doctor months ago about alternative options and his doctor replied that when people are faced with death they tend to look for a miracle? How many miracles do you see happen? My father is very much looking forward to his next visit with that particular doctor because that is how we feel? Even if DCA does not completely cure my father, to even imagine that it could have done this is a miracle! I truely believe my father would not be hear now if I had not started him on DCA. I am looking for pictures from christmas and a current picture of my father to share with everyone. Just do not give up hope regardless of what anyone tells you.


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Andre
unregistered user
Apr-08-07, 12:04 PM (PST)
 
8. "RE: Successful Results"
In response to message #0
 
   Dear friend

Please do CT SCANS...you can go to the doctor and ask for one.It´s very important,please.Now,it is the time to see if DCA works.Please report us about the scan result.It is possible to make a CT scan as fast as it is possible.We all would be greatful if you can do this,please..

all best for your dad..

André


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Joy
unregistered user
Apr-08-07, 05:26 PM (PST)
 
12. "RE: Successful Results"
In response to message #8
 
   >Dear friend
>
>Please do CT SCANS...you can go to the doctor and ask for
>one.It´s very important,please.Now,it is the time to see if
>DCA works.Please report us about the scan result.It is
>possible to make a CT scan as fast as it is possible.We all
>would be greatful if you can do this,please..
>
>all best for your dad..
>
>André

Hi,

I have advised my dad to request a scan in which we hope that the doctors will cooperate. The only problem is that up until my fathers surgery his was misdiagnosed. If they had known that the cancer was that bad they would have never opened him up. He had 2 MRI's prior to surgery and the tumor on the outside was never seen. They did not know the full extent until they opened him. So, I don't know how helpful the scan results will be. According to his doctors, they made it seem like it was common for a misdiagnosis due to the area of the tumor. We also have not told any of his doctors what he is taking.


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Sandramoderator
Member since Feb-27-07
1178 posts
Apr-08-07, 09:39 PM (PST)
Click to EMail Sandra Click to send private message to Sandra Click to view user profileClick to add this user to your buddy list  
13. "RE: Successful Results"
In response to message #12
 
What do we need a scan for? The doctors didn't even find all the cancer with a scan - they had to see it during surgery.

This man was was suffering from cachexia - which is a sign that death is near - and now he's gaining weight and is up and exercising! WOW! That is the BEST evidence that he is improving!

He wouldn't be gaining weight and exercising if his cancer were still advancing.


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Sandramoderator
Member since Feb-27-07
1178 posts
Apr-08-07, 09:47 PM (PST)
Click to EMail Sandra Click to send private message to Sandra Click to view user profileClick to add this user to your buddy list  
14. "RE: Successful Results"
In response to message #13
 
If we put all our faith in scans, none of us would still be here, reading and posting on this forum. Remember Omega3's scan? Now we have evidence to believe that being on DCA for a few more weeks (at a lower dose) was enough to produce results like this!


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Willis
Member since Feb-16-07
18 posts
Apr-09-07, 01:37 AM (PST)
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20. "RE: Successful Results"
In response to message #14
 
   All due respect, this isn't a faith-based enterprise. The way you determine whether DCA is working is not based on feelings.


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ConnieinReno
unregistered user
Apr-09-07, 00:43 AM (PST)
 
17. "RE: Successful Results"
In response to message #13
 
   Sandra,

I completely agree with you and think it's a waste of time and money getting a scan done. I should think a simple, less expensive, blood test to see where the cancer markers are at is probably more conclusive than getting a scan done.

After all, if the markers show a significant decrease then something is definitely working right for Joy's dad. I would also like to add that getting "phytonutrients" into a cancer patients system will play a big role in fighting cancer cell proliferation.

Connie


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blake
unregistered user
Apr-08-07, 11:43 PM (PST)
 
15. "RE: Successful Results"
In response to message #12
 
   Hi I was just wondering if your father was still on the anti rejection medicine while taking dca?


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Joy
unregistered user
Apr-09-07, 00:43 AM (PST)
 
18. "RE: Successful Results"
In response to message #15
 
   >Hi I was just wondering if your father was still on the anti
>rejection medicine while taking dca?


Yes, he still takes one of the medications. He was taking 2 different types of anti-rejection medications one of which he has been taken off of. They regulate the medication based on blood tests. They either increase or decrease. However, since the cancer he has been taking a lower dose due to the cancer keeping the immune system low.


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John A
Member since Mar-18-07
117 posts
Apr-09-07, 00:30 AM (PST)
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16. "RE: Successful Results"
In response to message #0
 
   Great News Joy,

Very encouraging for everyone. Thanks for keeping us informed.

Could you please share with us all the exact quantities of the other supplements that your father used?


Thank you

John A


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Joy
unregistered user
Apr-09-07, 01:03 AM (PST)
 
19. "RE: Successful Results"
In response to message #16
 
   >Great News Joy,
>
>Very encouraging for everyone. Thanks for keeping us
>informed.
>
>Could you please share with us all the exact quantities of
>the other supplements that your father used?
>
>
>Thank you

Hi,

Soybean , Omega 369, Pro-biotic Acidophilus, Noni Supreme, L-Glutamine 500 mg, Co-Q10 100 mg, He receives 2 times a day

B1 100 mg, Zinc 25 mg, He receives 1 time a day


Joy


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Prime3end
unregistered user
Apr-09-07, 02:37 AM (PST)
 
21. "RE: Successful Results"
In response to message #19
 
   Joy,

Since your father requires immune supression drugs, consider the recent work on rapamycin in rats, it had amazing results on rats and its an immune supressant drug, already approved. Here is a story on the work, very recently. Was or is he taking rapamycin????

TRIAL RESULTS

Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

BETHESDA, Md., April 1, 2007--Rapamycin, an FDA-approved drug normally used to help prevent the body from rejecting organ and bone marrow transplants and also used to coat cardiac stents, was highly effective in preventing the development of tobacco-related lung tumors in mice. In a study published in the April 1, 2007 issue of Clinical Cancer Research, researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, found that mice that were administered rapamycin one week after exposure to a very common tobacco-specific carcinogen showed a 90 percent decrease in the number of tumors, a 74 percent decrease in tumor size, and fewer abnormalities within their cancer cells. The scientists work also shows that mTOR, a protein targeted by rapamycin, plays a critical role in the early stages of development of certain lung tumors caused by tobacco exposure.



We estimate that there will be over 160,000 deaths from lung cancer this year, and 90 percent of those will be attributed to smoking. Quitting smoking reduces lung cancer risk by about 50 percent, said NCI Director John E. Niederhuber, M.D. By exploring methods of chemoprevention via agents such as rapamycin, we may be able to further reduce lung cancer risk.

Previous studies in mice have shown that nicotine and its metabolic byproduct, known as NNK, stimulate the activity of two proteins, Akt and mTOR, in normal cells that line the airways in the lungs. This activation makes the cells pre-cancerous. In addition, clinical studies have shown that Akt is activated in the majority of pre-cancerous lesions in smokers, and that Akt activation predicts shorter survival for non-small cell lung cancer patients, particularly for those in early stages or with small tumors. These studies suggested that Akt and mTOR are important elements in the formation and maintenance of tobacco-carcinogen induced lung tumors, and that targeting these proteins and the cellular pathway that they are associated with may be a realistic tactic for lung cancer chemoprevention. Because the most promising inhibitors of this pathway target mTOR as opposed to Akt, the researchers focused on an FDA-approved inhibitor of mTOR, rapamycin.

Investigators performed several experiments in mice to examine the effects of mTOR inhibition on new tumor formation and on established tumors. Mice were exposed to NNK (a carcinogen only found in tobacco) through injection into the peritoneum (the area that contains the abdominal organs). Rapamycin, which targets mTOR, was administered either one or 26 weeks after NNK administration. The group that was given rapamycin at week one was used to test the drug as a preventative agent. The group that received treatment at week 26 was used to test the effect on established tumors. A once daily dose given five out of seven days a week, which was a standard used in previous studies, was compared to an every-other-day, or ‘qod, regimen. Comparisons revealed that rapamycin levels were better maintained with an every-other-day administration.

Importantly, the levels of rapamycin achieved in mice were comparable to those in humans. On the daily regimen, which began on week 26, tumor size, the rate of tumor proliferation, and mTOR activity were reduced, but the rate at which tumor cells multiplied was unchanged. When rapamycin was administered one week after NNK, the every-other-day regimen was well tolerated and produced the best results in terms of tumor cell multiplication (90 percent reduction), cell abnormalities (changes in appearance, shape, etc.), and size (74 percent decrease). This was correlated with decreased proliferation of tumor cells and inhibition of mTOR.

Our studies provide an exciting link between exposure to an important tobacco carcinogen, NNK, and mTOR, said Phillip A. Dennis, M.D., Ph.D., head, Signal Transduction Section of NCI's Center for Cancer Research. The critical question is whether this approach would be safe and effective in smokers at high risk to develop lung cancer. Given that rapamycin is relatively inexpensive and FDA-approved for other indications, we are designing clinical trials in humans to address these questions and hope to have these answers in the near future.

Further research is needed to determine whether doses of rapamycin that achieve an anti-tumor effect in mice are similarly effective in humans, and whether giving a dose that would be sufficient for an anti-tumor effect would cause unacceptable levels of immune suppression or toxicity.

For more information on Dr. Denniss research, go to http://ccr.cancer.gov/Staff/Staff.asp?profileid=5727

For more information about cancer, please visit the NCI Web site at http://www.cancer.gov, or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237).

The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

--------------------------------------------------------------------------------
Reference: Granville C, Warfel N, Tsurutani J, Hollander C, Robertson M, Fox S, Veenstra T, Issaq H, Linnoila I, Dennis P. Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity and phenotypic progression of tobacco carcinogen-induced murine lung tumors. Clin Cancer Res. Vol.13, No. 7.
--------------------------------------------------------------------------------
CONTACT:
NCI Office of Media Relations
301-496-6641

My website and email, www.geocities.com/prime3end prime3end@yahoo.com


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Joy
unregistered user
Apr-09-07, 03:09 AM (PST)
 
22. "RE: Successful Results"
In response to message #21
 
   Hi,

The anti-rejection medication that my father is currently taking is called Prograf. The anti-rejection medicine that they stopped him from taking is called Azathioprine. He used to take both.

Thank you for the useful information.

Joy


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Prime3end
unregistered user
Apr-09-07, 03:47 AM (PST)
 
23. "RE: Successful Results"
In response to message #22
 
   Now this is interesting. The web says, that Prograf is "tacrolimus", ,, while "Sirolimus" is rapamycin with a similar name, could it be that your father is doing the first multi-agent trial of rapamycin , or an analogue of it, and DCA???? Is it possible or even likely that he is greatly responding because he is using both agents at the same time???!!!!, just thought I should point this out in case your Dad's great results turn out to be unrepeatable in other folks who aren't taking Prograf. Most obviously won't be taking Prograf. If I get sick I'd try damn hard to get my hands on some, but I will wait for one of the doctors to weigh in on this discussion. I'm no chemist thats for sure. I must say that I am overjoyed with your Dad's results thus far, and wish you both my absolute blessings. Thanks to your Dad and you for not going gently into that good night. The doctors are mostly all cowardly. I can remember when they were researchers and not afraid to use research to save the patients life, especially when all else had failed to help.

Prime3end
Wikipedia definitions below.

Sirolimus
From Wikipedia, the free encyclopedia
Jump to: navigation, search


Sirolimus
Systematic (IUPAC) name
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,
26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,
27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-
-
1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-
hexamethyl-23,27-epoxy-3H-pyrido-
oxaazacyclohentriacontine-1,5,11,28,29
(4H,6H,31H)-pentone
Identifiers
CAS number 53123-88-9
ATC code L04AA10
PubChem 6436030
DrugBank APRD00178
Chemical data
Formula C51H79NO13
Mol. mass 914.172 g/mol
Pharmacokinetic data
Bioavailability 20%, less after eating food rich in fat
Protein binding 92%
Metabolism Hepatic
Half life 57–63 hours
Excretion Mostly faecal
Therapeutic considerations
Licence data EU US

Pregnancy cat. C(AU) C(US)

Legal status ℞-only(US)

Routes Oral
Sirolimus (INN) is a relatively new immunosuppressant drug used to prevent rejection in organ transplantation, and is especially useful in kidney transplants. It is also known as rapamycin. Sirolimus is a macrolide antibiotic ("-mycin") first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from an island called Rapa Nui, better known as Easter Island. It is marketed under the trade name Rapamune by Wyeth.

Interestingly, sirolimus was originally developed as an antifungal agent. However, this was abandoned when it was discovered that it had potent immunosuppressive and antiproliferative properties.

Contents
1 Mechanism of action
2 Use in transplant
3 Anti-proliferative effects
3.1 Cancer
4 References
5 External links


Mechanism of action
Despite its similar name, it is not a calcineurin inhibitor like tacrolimus or cyclosporin. However, it has a similar suppressive effect on the immune system. Sirolimus inhibits the response to interleukin-2 (IL-2) and thereby blocks activation of T- and B-cells. In contrast, tacrolimus and cyclosporine inhibit the production of IL-2.

The mode of action of sirolimus is that it binds to the cytosolic protein FK-binding protein 12 (FKBP12) in a similar way to tacrolimus. However, unlike the tacrolimus-FKBP12 complex which inhibits calcineurin (PP2B), the sirolimus-FKBP12 complex inhibits the mammalian target of rapamycin (mTOR) pathway through direct binding to the mTOR Complex1 (mTORC1). mTOR is also called FRAP (FKBP-rapamycin associated protein) or RAFT (rapamycin and FKBP target). FRAP and RAFT are actually more accurate names since they reflect the fact that rapamycin must bind to FKBP12 first, and only the FKBP12-rapamycin complex can bind FRAP/RAFT/mTOR.


Use in transplant
The chief advantage sirolimus has over calcineurin inhibitors is that it is not toxic to kidneys. Transplant patients maintained on calcineurin inhibitors long-term tend to develop impaired kidney function or even chronic renal failure, and this can be prevented by use of sirolimus instead. It is particularly advantageous in patients with kidney transplants for hemolytic-uremic syndrome as this disease is likely to recur in the transplanted kidney if a calcineurin-inhibitor is used.

Sirolimus can also be used alone or in conjunction with calcineurin inhibitors and/or mycophenolate mofetil, to provide steroid-free immunosuppression regimes. As impaired wound healing is a possible side effect of sirolimus, some transplant centres prefer not to use it immediately after the transplant operation, and start to give it after a period of weeks or months. Its optimal role in immunosuppression has not yet been determined and is the subject of a number of ongoing clinical trials.


Anti-proliferative effects
The anti-proliferative effect of sirolimus has also been used in conjunction with coronary stents to prevent restenosis in coronary arteries following balloon angioplasty. The sirolimus is formulated in a polymer coating that affords controlled release through the healing period following coronary intervention. Several large clinical studies have demonstrated lower restenosis rates in patients treated with sirolimus eluting stents when compared to bare metal stents, resulting in fewer repeat procedures. A sirolimus eluting coronary stent is marketed by Cordis, a division of Johnson & Johnson, under the tradename Cypher. It has been proposed, however, that such stents may increase the risk of vascular thrombosis.


Cancer
The anti-proliferative effects of sirolimus may have a role in treating cancer. Recently, it was shown that sirolimus inhibited the progression of dermal Kaposi's sarcoma in patients with renal transplants. Other mTOR inhibitors such as temsirolimus (CCI-779) or everolimus (RAD001) are being tested for use in cancers such as glioblastoma multiforme and mantle cell lymphoma.

Combination therapy of doxorubicin and sirolimus has been shown to drive AKT-positive lymphomas into remission in mice. Akt signalling promotes cell survival in Akt-positive lymphomas and acts to prevent the cytotoxic effects of chemotherapy drugs like doxorubicin or cyclophosphamide. Sirolimus blocks Akt signalling and the cells lose their resistance to the chemotherapy. Bcl-2-positive lymphomas were completely resistant to the therapy; nor are eIF4E expressing lymphomas sensitive to sirolimus. Rapamycin showed no effect on its own.

As with all immunosuppressive medications, rapamycin decreases the body's inherent anti-cancer activity and allows some cancers which would have been naturally destroyed to proliferate. Patients on immunosuppressive medications have a 10- to 100-fold increased risk of cancer compared to the general population. Furthermore, people who currently have or have already been treated for cancer have a higher rate of tumor progression and recurrence than patients with an intact immune system.


References
^ Pritchard DI (2005). "Sourcing a chemical succession for cyclosporin from parasites and human pathogens". Drug Discovery Today 10 (10): 688–691. PMID 15896681.
^ Shuchman M (2006). "Trading restenosis for thrombosis? New questions about drug-eluting stents". N Engl J Med 355 (19): 1949–52. PMID 17093244.
^ Sun S, Rosenberg L, Wang X, Zhou Z, Yue P, Fu H, Khuri F (2005). "Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition". Cancer Res 65 (16): 7052–8. PMID 16103051. Free full text
^ Chan S (2004). "Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer". Br J Cancer 91 (8): 1420–4. PMID 15365568.
^ Cold Spring Harbor Laboratory. "Combination Therapy Drives Cancer Into Remission", ScienceDaily, March 18, 2004. Retrieved on January 10, 2007.
^ Cold Spring Harbor Laboratory (March 17, 2004). Combination Therapy for Cancer Shows Promise. Press release. Retrieved on 2007-01-10.
^ Novak, Kristine. Disruption of Akt signaling with the drug rapamycin reverses tumor chemoresistance in a mouse model of lymphoma. The Signaling Gateway. Retrieved on January 10, 2007.


External links
Rapamune official website
Links to external chemical sources
v • d • eImmunosuppressants (L04)
Abatacept, Abetimus, Adalimumab, Afelimomab, Anakinra, Alefacept, Antilymphocyte immunoglobulin (horse), Antithymocyte immunoglobulin (rabbit), Aselizumab, Atlizumab, Atorolimumab, Azathioprine, Basiliximab, Belatacept, Belimumab, Bertilimumab, Cedelizumab, Ciclosporin, Citilimumab, Clenoliximab, Daclizumab, Difirolimus, Dofosirolimus, Dorlimomab aritox, Eculizumab, Efalizumab, Elsilimomab, Enlimomab, Enlimomab pegol, Erlizumab, Etanercept, Everolimus, Faralimomab, Fontolizumab, Galiximab, Gavilimomab, Gifosirolimus, Golimumab, Gomiliximab, Gusperimus, Infliximab, Inolimomab, Ipilimumab, Keliximab, Leflunomide, Lerdelimumab, Lumiliximab, Maslimomab, Mepolizumab, Metelimumab, Methotrexate, Morolimumab, Muromonab-CD3, Mycophenolic acid, Natalizumab, Nerelimomab, Ocrelizumab, Odulimomab, Omalizumab, Pascolizumab, Pexelizumab, Pimecrolimus, Reslizumab, Rovelizumab, Ruplizumab, Safosirolimus, Siplizumab, Sirolimus, Tacrolimus, Talizumab, Telimomab aritox, Teneliximab, Thalidomide, Ticilimumab, Tilolizumab, Tocilizumab, Toralizumab, Torolimus, Vapaliximab, Vepalimomab, Visilizumab, Zanolimumab, Ziralimumab, Zolimomab aritox

NEXT IS PROFGAF DEFINITION FROM WIKIPEDIA:::::

Tacrolimus (also FK-506 or Fujimycin) is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.

It is an immunosuppressive drug whose main use is after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.

It is also used in a topical preparation in the treatment of severe atopic dermatitis (often called "eczema"), as have ciclosporin and azathioprine with much less success. It has also been used after bone marrow transplants and for severe refractory uveitis. It is also prescribed for the treatment of the skin condition vitiligo.

Contents
1 History
2 Pharmacology
3 Indications
3.1 Immunosuppresion following transplantation
3.2 Dermatological use
4 Contraindications and Precautions
5 Side effects
5.1 From oral and intravenous administration
5.2 From topical use
5.3 Cancer risks
6 References
7 External links


History
Tacrolimus was discovered in 1987 by a Japanese team headed by T. Goto, T. Kino and H. Hatanaka; it was the first macrolide immunosuppressant discovered. Like ciclosporin, it was found in a soil fungus, although it is produced by a type of bacteria, Streptomyces tsukubaensis. The name tacrolimus is reportedly derived from 'Tsukuba macrolide immunosuppressant'.

The drug is owned by Astellas Pharma Inc. (Merging of Fujisawa Pharmaceutical Co.,Ltd. and Yamanouchi Pharmaceutical Co., Ltd as of April 1, 2005) and is sold under the tradename Prograf®. It is sometimes referred to as FK-506, an early name relating to its action. It was first approved by the Food and Drug Administration (FDA) in 1994 for use in liver transplantation, this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, and limb transplants.


Pharmacology
Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. Although this activity is similar to ciclosporin, studies have shown that the incidence of acute rejection is reduced by tacrolimus use over ciclosporin.citation needed


Indications

Immunosuppresion following transplantation
It has similar immunosuppressive properties to ciclosporin, but is much more potent in equal volumes. Also like ciclosporin it has a wide range of adverse interactions, including that with grapefruit which increases plasma-tacrolimus concentration. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study.


Dermatological use
As an ointment (Protopic®), tacrolimus is a recent addition in the treatment of eczema, particularly atopic eczema. It suppresses inflammation in a similar way to steroids, it is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects. It may therefore be used continuously on the body and applied to the thinner skin over the face and eyelids.


Contraindications and Precautions
breast-feeding
hepatic disease
immunosuppression
infants
infection
intravenous administration
neoplastic disease
occlusive dressing
oliguria
pregnancy
QT prolongation
skin cancer
sunlight (UV) exposure

Side effects

From oral and intravenous administration
Side effects can be severe and include blurred vision, liver and kidney problems (it is nephrotoxic), seizures, tremors, hypertension, hypomagnesemia, diabetes mellitus, hyperkalemia, itching, insomnia, confusion, loss of appetite, hyperglycemia, weakness, depression, cramps, and neuropathy, as well as potentially increasing the severity of existing fungal or infectious conditions such as herpes zoster or polyoma viral infections.


From topical use
A common side effect of tacrolimus ointment, if used over a wide area, is to cause a burning or itching sensation on the first one or two applications.


Cancer risks
Further information: Eczema#Immunomodulators
Tacrolimus and a related drug for eczema (pimecrolimus) were suspected of carrying a cancer risk, though the matter is still a subject of controversy. The FDA issued a health warning in March 2005 for the drug, based on animal models and a small number of patients. Until further human studies yield more conclusive results, the FDA recommends that users be advised of the potential risks. Whereas current practice by UK dermatologists is not to consider this a significant real concern and they are increasingly recommending the use of these new drugs.

Dermatologists agree that the drug should be used as a second-line remedy only after conventional methods of treatment have failed.


References
^ Kino T, Hatanaka H, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H (1987). "FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.". J Antibiot (Tokyo) 40 (9): 1249-55. PMID 2445721.
^ Pritchard D (2005). "Sourcing a chemical succession for cyclosporin from parasites and human pathogens.". Drug Discov Today 10 (10): 688-91. PMID 15896681. Supports source organism, but not team information
^ Liu J, Farmer J, Lane W, Friedman J, Weissman I, Schreiber S (1991). "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.". Cell 66 (4): 807-15. PMID 1715244.
^ McCauley, Jerry (2004-05-19). Long-Term Graft Survival In Kidney Transplant Recipients. Slide Set Series on Analyses of Immunosuppressive Therapies. Medscape. Retrieved on June 6, 2006.
^ N H Cox and Catherine H Smith (December 2002). Advice to dermatologists re topical tacrolimus (DOC). Therapy Guidelines Committee. British Association of Dermatologists.

External links
Prograf® prescribing information at Fujisawa
Tacrolimus (Protopic Cream) FDA advisory page (for eczema treatment)
Pimecrolimus (Elidel Cream) FDA adivisory page (for eczema treatment)
Links to external chemical sources
v • d • eImmunosuppressants (L04)
Abatacept, Abetimus, Adalimumab, Afelimomab, Anakinra, Alefacept, Antilymphocyte immunoglobulin (horse), Antithymocyte immunoglobulin (rabbit), Aselizumab, Atlizumab, Atorolimumab, Azathioprine, Basiliximab, Belatacept, Belimumab, Bertilimumab, Cedelizumab, Ciclosporin, Citilimumab, Clenoliximab, Daclizumab, Difirolimus, Dofosirolimus, Dorlimomab aritox, Eculizumab, Efalizumab, Elsilimomab, Enlimomab, Enlimomab pegol, Erlizumab, Etanercept, Everolimus, Faralimomab, Fontolizumab, Galiximab, Gavilimomab, Gifosirolimus, Golimumab, Gomiliximab, Gusperimus, Infliximab, Inolimomab, Ipilimumab, Keliximab, Leflunomide, Lerdelimumab, Lumiliximab, Maslimomab, Mepolizumab, Metelimumab, Methotrexate, Morolimumab, Muromonab-CD3, Mycophenolic acid, Natalizumab, Nerelimomab, Ocrelizumab, Odulimomab, Omalizumab, Pascolizumab, Pexelizumab, Pimecrolimus, Reslizumab, Rovelizumab, Ruplizumab, Safosirolimus, Siplizumab, Sirolimus, Tacrolimus, Talizumab, Telimomab aritox, Teneliximab, Thalidomide, Ticilimumab, Tilolizumab, Tocilizumab, Toralizumab, Torolimus, Vapaliximab, Vepalimomab, Visilizumab, Zanolimumab, Ziralimumab, Zolimomab aritox

Retrieved from "http://en.wikipedia.org/wiki/Tacrolimus";
Categories: Immunosuppressive agents | Macrolide antibiotics


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Prime3end
unregistered user
Apr-09-07, 04:04 AM (PST)
 
24. "RE: Successful Results"
In response to message #23
 
   Please relate your fathers dosage of Prograf, and has the dosage changed at all since his transplant.


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Prime3end
unregistered user
Apr-09-07, 04:23 AM (PST)
 
25. "RE: Successful Results"
In response to message #24
 
   Joy,

I'm glad they took him off the other supressant drug, its bad news per my limited lookup of its side effects on the web. One side effect was cancer.


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Joy
unregistered user
Apr-09-07, 04:27 AM (PST)
 
26. "RE: Successful Results"
In response to message #24
 
   >Please relate your fathers dosage of Prograf, and has the
>dosage changed at all since his transplant.


Hi,

My father only takes 1 mg of Prograf which is changed monthly depending on blood results. He takes it 2 times a day, the dosage would stay the same, increase or decrease by 1 mg twice a day depending on the results. However since his diagnosis he has remained on only 1 mg 2 times a day.

Joy


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Prime3end
unregistered user
Apr-09-07, 04:33 AM (PST)
 
27. "RE: Successful Results"
In response to message #26
 
   Thanks Joy!! Did you read about the Prograf and Rapamycin I posted above???? You will find it most interesting. I don't think Prograf is detrimental to the DCA story. I think it may well become a part of it's success!! Both Prograf and Rapamycin has shown early results against cancers!!!!! Very Cool!!

Prime3end


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sadeoo
unregistered user
Apr-09-07, 11:46 AM (PST)
 
28. "RE: Successful Results"
In response to message #27
 
   Hi joy,

Thank you very much for your great reply which will very helpful for my whole family. But I still have one question, please inform to me.

Could you please tell me the exact quantities of DCA? For now, I am not clear with the DCA dosage your father taking,1/4 teaspoon means 12.5mg? In my country, we used different size teaspoon. In fact my family wants to give a try with DCA. The dosage of DCA will be the key point for the whole process.

June


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Bobby
unregistered user
Apr-09-07, 02:54 PM (PST)
 
29. "RE: Successful Results"
In response to message #28
 
   >Hi joy,
>
>Thank you very much for your great reply which will very
>helpful for my whole family. But I still have one question,
>please inform to me.
>
> Could you please tell me the exact quantities of DCA? For
>now, I am not clear with the DCA dosage your father
>taking,1/4 teaspoon means 12.5mg? In my country, we
>used different size teaspoon. In fact my family wants to
>give a try with DCA. The dosage of DCA will be the key point
>for the whole process.
>
>June

Hi June,
If you go on Google enter:
www.toplinedigitalscales.com

Note: Do not click on this address
direct, enter on Google.

Click on the second result on Google, should be:
Top Line Digital Scales.
***Todays Special.***

You can measure any Dosage.
Accurate to 1mg.

If you have any problem with Google, Post your email address, and I WILL email you the Web Link
to click on.
Bobby


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Sandramoderator
Member since Feb-27-07
1178 posts
Apr-09-07, 05:29 PM (PST)
Click to EMail Sandra Click to send private message to Sandra Click to view user profileClick to add this user to your buddy list  
31. "RE: Successful Results"
In response to message #28
 
Hi June,

1/4 teaspoon (from Joy's post) equals about 1000mg (1gram)


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believer
unregistered user
Apr-09-07, 04:42 PM (PST)
 
30. "RE: Successful Results"
In response to message #0
 
   If your giving him 1/4 teaspoon once a day, what is his weight for that amount? Because that would be a big factor. My sister has dropped to around 100lbs. So we don't want to be giving her to much or to little. Because not enough of the dca will make it not work either.
Thanks and keep posting please.
Believer


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Joy
unregistered user
Apr-09-07, 11:46 PM (PST)
 
32. "RE: Successful Results"
In response to message #30
 
   >If your giving him 1/4 teaspoon once a day, what is his
>weight for that amount? Because that would be a big factor.
>My sister has dropped to around 100lbs. So we don't want to
>be giving her to much or to little. Because not enough of
>the dca will make it not work either.
>Thanks and keep posting please.
>Believer


Hi,

My father weighed 133lbs. when I started him on DCA, he is now at 144lbs. and still at the same dose.

Joy


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Sade00
unregistered user
Apr-10-07, 01:11 PM (PST)
 
33. "RE: Successful Results"
In response to message #32
 
   Hi joy

According to your posting, your father is taking DCA once every morning. Could you please tell me that DCA along with several of nutriments should be taken with an empty stomach or after breakfast?
In addition, there are several nutriments which your father taking two times one day; those nutriments should be taken after lunch or dinner?

PS: Many thanks to Sandra and Bobby.

June


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DerekSmith
Member since Mar-30-07
63 posts
Apr-10-07, 06:48 PM (PST)
Click to EMail DerekSmith Click to send private message to DerekSmith Click to view user profileClick to add this user to your buddy list  
34. "RE: Successful Results"
In response to message #33
 
   Hi Joy,

Could you relate to us please what your dad's typical diet is.

Thanks
Derek


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Joy
unregistered user
Apr-11-07, 04:36 AM (PST)
 
36. "RE: Successful Results"
In response to message #34
 
   >Hi Joy,
>
>Could you relate to us please what your dad's typical diet
>is.
>
>Thanks
>Derek

Hi,

Up until recently he was not eating much of anything. He is not on a strict diet however, we try to keep him from eating carbohydrates, dairy, fried foods. He does eat them, just very limited amounts. Recently, he has been craving and wanting to eat a lot of cheese which he is not aloud to have. He has always had to watch his diet because of his heart. For the last 20 years he had to eat foods low in sodium, starches, trans fat, and cholesterol. He eats foods high in protein and a lot of vegetables.

Joy


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Joy
unregistered user
Apr-11-07, 04:08 AM (PST)
 
35. "RE: Successful Results"
In response to message #33
 
   >Hi joy
>
>According to your posting, your father is taking DCA once
>every morning. Could you please tell me that DCA along with
>several of nutriments should be taken with an empty stomach
>or after breakfast?
>In addition, there are several nutriments which your father
>taking two times one day; those nutriments should be taken
>after lunch or dinner?
>
>PS: Many thanks to Sandra and Bobby.
>
>June

Hi,

My father takes the DCA alone in the morning with no food. He usually doesnt eat for atleast 1 hour. He takes his vitamins at 1pm and 1am everyday, after lunch and before bed.

Joy


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George
unregistered user
Apr-11-07, 08:23 PM (PST)
 
37. "RE: Successful Results"
In response to message #0
 
   My daugther (17) has been fighting a rare form of childhood cancer called Rhabdomyoscarcoma since Feb of 2004. She was stage 4 then. While we have had some success with radiation, chemo and surgery, the cancer just keeps coming back.
I was given information about the University of Alberta trail that is trying to get underway, but if I don't get moving NOW, it will be too late for my daughter.
Questions if I may,
- you indicated that you "purchased" DCA where and how?
- Some sights talk about Vet DCA. Is this the same?
- How did you know what dose to give your father?

I would GREATLY appreciate any help.

George
at

millerg@oakgov.com


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leif
unregistered user
Apr-13-07, 12:52 PM (PST)
 
39. "RE: Successful Results"
In response to message #37
 
   >- you indicated that you "purchased" DCA where and how?

She said she got it from www.buydca.com

"Hi,
I ordered the DCA from buydca.com. I am sorry to hear about your brother, I will pray for him. "


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Joy
unregistered user
Apr-15-07, 00:02 AM (PST)
 
43. "RE: Successful Results"
In response to message #37
 
   >My daugther (17) has been fighting a rare form of childhood
>cancer called Rhabdomyoscarcoma since Feb of 2004. She was
>stage 4 then. While we have had some success with
>radiation, chemo and surgery, the cancer just keeps coming
>back.
>I was given information about the University of Alberta
>trail that is trying to get underway, but if I don't get
>moving NOW, it will be too late for my daughter.
>Questions if I may,
>- you indicated that you "purchased" DCA where and how?
>- Some sights talk about Vet DCA. Is this the same?
>- How did you know what dose to give your father?
>
>I would GREATLY appreciate any help.
>
>George
>at
>
>millerg@oakgov.com

Hi,

I am very sorry that I did not reply sooner, I have not been able to access the computer. I purchased the dca from buydca.com. I actually purchased the vet dca.

Joy


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Tony
unregistered user
Apr-21-07, 03:55 PM (PST)
 
48. "RE: Successful Results"
In response to message #37
 
   Since I am new to this forum, I have tried numerous alternative solutions. The DCA I am currently taking is just another one of these alternatives. I am hoping that positive results will alos occur from this product.
That said, I would like to share some of the diets and products I have used, that have produced a significant change in my prostate cancer.
First occured when I changed my diet. I went onto a macrobiotic diet, which helped restore my strenght and decrease my PSA levels, within 3 months my PSA went from 7 plus to just over 4.
Second, Taking megadoseages of enzymes.
Third, bloodroot.
You can research all of these on the internet and I will give you a number to call for additional information about enzymes and bloodroot.
Ask for Kelly, he is extremely knowledgeable and personalable.
He has his own lab and produces the enzymes and bloodroot.

I hope information will benefit your daughter and anyone else who reads this posting.

The telephone number is 1-800-962-7863

Tony


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Sandramoderator
Member since Feb-27-07
1178 posts
Apr-13-07, 10:13 PM (PST)
Click to EMail Sandra Click to send private message to Sandra Click to view user profileClick to add this user to your buddy list  
40. "RE: Successful Results"
In response to message #0
 
Joy,
Here is a supplement you might want to consider:

Fucoidan - brown seaweed
Brown seaweed extract effective against cancer: boosts immunity, induces apoptosis from inside the mitochondria, enhances macrophages activity. Especially good against cancers of digestive tract.

http://www.thedcasite.com/dcaforum/DCForumID10/28.html


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Joy
unregistered user
Apr-15-07, 00:03 AM (PST)
 
44. "RE: Successful Results"
In response to message #40
 
   Thanks Sandra for all your help!

Joy


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Simon
unregistered user
Apr-14-07, 01:30 PM (PST)
 
41. "RE: Successful Results"
In response to message #0
 
   lab mice are immuno-supressed to grow cancer in their system;
your father is taking anti-rejection drug - i.e. immuno-supressed;
is there a co-relation for the good results??
do we need to reduce our immune system for dca to work?


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Sandramoderator
Member since Feb-27-07
1178 posts
Apr-14-07, 04:47 PM (PST)
Click to EMail Sandra Click to send private message to Sandra Click to view user profileClick to add this user to your buddy list  
42. "RE: Successful Results"
In response to message #41
 
Read the other testimonials. People are getting results who are not on immuno-supressant drugs. A healthy immune system is what prevents people from getting cancer in the first place.


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Joy
unregistered user
Apr-15-07, 00:15 AM (PST)
 
45. "RE: Successful Results"
In response to message #41
 
   >lab mice are immuno-supressed to grow cancer in their
>system;
>your father is taking anti-rejection drug - i.e.
>immuno-supressed;
>is there a co-relation for the good results??
>do we need to reduce our immune system for dca to work?


Hi,

That is very interesting however, I am not to sure because cancer is actually a side effect from the anti-rejection medicine. According to the doctors, my dad's cancer maybe the result of the suppressed immune system. They were able to decrease the anti-rejection medicine because of the cancer keeping the immune system suppressed.

Joy


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James Kneller
unregistered user
Apr-15-07, 07:07 AM (PST)
 
46. "RE: Successful Results"
In response to message #0
 
   Hi Joy,

It has been a week since your first posting, I was wondering whether you had an update of progress. I am sure everyone would be very interested to know. I would be particularly interested to know whether your father has been able to go futher without pain medication. James.


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Joy
unregistered user
Apr-16-07, 05:12 AM (PST)
 
47. "RE: Successful Results"
In response to message #46
 
   >Hi Joy,
>
> It has been a week since your first posting, I was
>wondering whether you had an update of progress. I am sure
>everyone would be very interested to know. I would be
>particularly interested to know whether your father has been
>able to go futher without pain medication. James.

Hi,

He is doing very well, he is actually here with me in Florida this week which is why I haven't been keeping up with the postings (sorry). He flew in yesterday and will be here until the 25th. In fact he is doing so well that he completely wore both me and my sister out yesterday. He is still taking his pain medication. We try to keep it as low as possible. Recently he had his catheter changed which causes discomfort in which he relied a little more on the pain medication but overall he is still steadily improving. He did request for blood work which was done on the 9th and we should have the blood results within a couple of days. As soon as I have any information I will let everyone know.

Thanks
Joy


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Doug
unregistered user
Apr-27-07, 01:22 PM (PST)
 
50. "RE: Successful Results"
In response to message #46
 
   Hi Joy, how's your father's test results


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Joy
unregistered user
Apr-28-07, 11:46 PM (PST)
 
52. "RE: Successful Results"
In response to message #50
 
   >Hi Joy, how's your father's test results


Hi,

My father had blood tests taken that were requested from his heart team which is routinely done once a month to monitor his immune system. With his most recent tests he requested that the doctor do a more thorough exam and check for any abnormalities. The heart coordinator advised my dad that the blood work looked good however his needed to increase his anti-rejection medication to 3 and 3. Which means they want him to take 3 pills 3 times a day and up until this point he has been taking only 1 and 1. According to the coordinator, they previously did not need to increase the anti-rejection medication due to the cancer keeping the immune system low. So, now we are wondering if it is possible that the cancer is dying and no longer dominating the immune system. Also, we are not sure if we should listen and taken the additional immune suppressants. I don't know if it will hurt his progression with the cancer or risk his heart rejecting. He is still doing really well with no side effects and a healthy appetite. I will keep everyone posted as to his condition.

Joy


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sade00
Member since Mar-12-07
5 posts
May-03-07, 04:30 PM (PST)
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55. "RE: Successful Results"
In response to message #52
 
   Hi Joy

Thank you for posting your father's condition. I am so happy to hear that he is doing very well.

My brother had received a transplant operation in 2006. three month ago ,he was found a tumor in his gland.My brother will start to try DCA next week.
So, i want to know whether you change the time for giving prograf to your father while he taken DCA? Beacuse there is a fix timetable for taken anti-rejection medication everyday.

Thank you,look forward to hearing from you soon.

Best wishes

Connie


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pssadm
Member since Jul-21-07
2 posts
Jul-22-07, 02:24 AM (PST)
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56. "RE: Successful Results"
In response to message #0
 
   Hi Joy,

I don't see any updates since May-03-07. I was just wondering how your father is doing and if they've determined the status of his cancer?

Also given that the DCABUY.COM site is now down, how will one go about ordering the DCA?

Wishing you & your family the absolute best in health!

Ben.


>My father Terry who is 62, was diagnosed in September of
>2006 with a very rare form of bladder cancer called
>adenocarcinoma which is only found in 1 to 2 percent of
>bladder cancer patients. This form of cancer is highly
>aggressive and as a result was given approximately 6 months
>to 1 year to live. After the initial diagnosis, he
>underwent 2 surgeries. The first to remove the tumor from
>inside the bladder and second to remove the bladder
>entirely. The doctors were unsuccessful with removing the
>bladder due to the extent of the cancer growth. The tumor
>was actually on top of the bladder as well as attached to
>the peritoneum making it impossible to remove. The doctors
>also stated that pathology results had confirmed that the
>cancer was microscopically everywhere. To make matters
>worse, my father had received a heart transplant in July of
>2002 due to heart disease. Because of his heart transplant
>he must take anti-rejection medications to keep his immune
>system suppressed. The immune system must be close to
>nonexistent to prevent his heart from rejecting. This has
>prevented him from having any form of cancer treatment. The
>doctors explained how there was nothing that could be done
>and basically sent him home to die. Since his diagnosis I
>have been researching for a cure with minimal side effects
>because of the extensive list of medications that my father
>is currently taking, which is about 25 pills a day. I had
>been emailing a doctor on-line with concerns of my fathers
>eating habits, he had dropped weight from 158lbs. to 133lbs.
>and was experiencing nausea, vomiting, dizziness. The
>doctor stated that my father was suffering from cachexia,
>which is common in final stages of cancer. It where the
>body actually eats itself and that I should purchase a
>product called Haelan 951. I later found that Haelan
>products were more than I could afford so I looked at the
>contents and purchased them individually from a vitamin
>supplier. At that same time I found and purchased DCA and
>began treatment for my father. Today has been four weeks of
>treatment, my father uses 1/4 teaspoon of DCA mixed with 8
>ounces of water once a day in the morning along with
>vitamins Co Q-10, Soybean, L-glutamine, Omega 369,
>Pro-biotic Acidophilus, Noni, B1, and Zinc. Within 2 weeks
>of treatment he had noticeable improvements in appetite and
>was experiencing less nausea. Currently, he has not
>experienced any vomiting, nausea, or dizziness. He now
>weighs 144lbs. which is an 11 lbs weight gain in about 2
>weeks, his appetite has greatly improved, he is now walking
>on his own which he was unable to do prior to treatment and
>amazingly is exercising. He has also regained muscles in
>his arms along with the color to his skin. He experiences
>bladder spasms thats directly related to the tumor on the
>bladder that has also subsided. There is no doubt in my
>mind or my families that DCA is the direct result of his
>improvements, simply because my father has not received any
>other form of treatment. I would also like to add that he
>has not experienced any side effects. My mother also
>informed me that my father went 3 and 1/2 hours without his
>pain medication yesterday and did not complain.
>Unfortunately we have not had any CT scans or monitoring
>from his doctors due to their lack of support but we can
>clearly see that something positive is happening. If anyone
>has any questions please feel free to ask, I will do
>anything I can to help.
>
>God Bless
>Joy


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graystranger
Member since Aug-29-07
1 posts
Aug-30-07, 06:33 AM (PST)
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57. "RE: Successful Results"
In response to message #0
 
   Hi. I'm worried my Dad might have lung cancer. We're still waiting for catscan results, but he's coughing and loosing weight. I'm not waiting for a final diagnosis. I am starting to do whatever I can NOW. I'm trying to find out more about people who are taking DCA. How is your father doing right now? We haven't seen a post from you in a while. Still taking DCA?


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Earlz
Member since Aug-5-07
22 posts
Sep-06-07, 01:11 PM (PST)
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58. "RE: Successful Results"
In response to message #0
 
   That's great news I pray for your dads continued success


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