The dose that I will be using is 12.5mg per Kilogram divided into two doses.This comes from previous human use studies. Which for my weight comes out to 1000mg twice a day. I had the Sodium Dichloroacetate powder made into 500mg capsule. I will be taking them on a full stomach and with approximately 16 oz. of water. In order to lower the risk of side effects it has been suggested in some research studies that “ DCA can cause a reversible peripheral neuropathy that may be related to thiamine deficiency and may be ameliorated or prevented with thiamine supplementation. “ (1) The use of thiamine 100mg or more should be used concomittantly with the DCA. I personal am thinking of using Benofotiamine a fat-soluble and more bioavailable and physiologically active form of thiamine. (2)Benofotiamine has been shown to be an effective treatment for patients with diabetic perpherial neuropathy. Though we really don't know what efffect the use of thiamine will have on the Cancer Cell assuming that DCA has any effect on cancer in humans.

After reviewing the research I think that Dr. Michelakis played down adverse effects of DCA. Know doubt DCA has way less adverse effects then conventional cyto-toxic chemotherapy but this drug is not completely benign. Apparently doses greater the 25mg per Kilogram increase the risk of these side effects. One other sugestion would be making sure you have a recent liver function test which you can then follow up after being on the DCA for a week or two. Since DCA can rise liver enzymes.

Remember all this information is just extrapolation of data and no one has the answer till studies are done.

If DCA research translates over to humans this will be a great step forward in cancer treatment.

For those whom can’t wait for human research studies to become available. I wish you the best and never give up hope

And thanks for the kind words.

Blessings,

Omega3

(1) Metabolism. 1989 Nov;38(11):1124-44
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2554095&query_hl=1&itool=pubmed_docsum

(2) Altern Med Rev. 2006 Sept;11(3):238-242
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17217325&query_hl=7&itool=pubmed_docsum