You brought me to a new possibility when you said:

"Interference with the tyrosine degradation pathway may be just one way that dca can lose its effect and the cause may be quite subtle. For instance if not broken down, the tyrosine catabolite succinylacetone inhibits aminolevulinic acid dehydratase, which increases delta aminolevlinic acid (also known as 5-ALA) which induces iron release from ferritin via free radical production. High levels of iron are drivers of tumour growth and oxidative damage."

This implies that DCA may icrease the effects of artesimin. The latter is susd mainly for malaria but some are experimenting it in the context of cancer. Artesimn uses iron as its main reactive component. I will explore further this path.

For reference on artesimn: http://www.nutritionaloncology.org/Artemisinin.html

Cheers
Didier PH Martin, PhD.